The US Food and Drug Administration (FDA) has just approved a new early-stage breast cancer treatment called Nerlynx (neratinib). According to the FDA, Nerlynx is the first extended adjuvant treatment of early-stage, HER2-positive breast cancer.
Extended adjuvant treatment is a type of therapy that patients take after an initial treatment to lower their risk of the cancer coming back even further. Nerlynx was designed for adult breast cancer patients who've been previously treated with a regimen including trastuzumab. Keep reading for more...
HER2-positive breast cancers are aggressive tumours that can spread to other parts of your body...
Richard Pazdur, director of the FDA’s Oncology Center of Excellence, explains that HER2-positive breast cancers are aggressive tumours that can spread to other parts of the body. Now that Nerlynx has been approved, patients with this type of breast cancer
can help stop the cancer
from coming back.
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Nerlynx works by blocking several enzymes that promote breast cancer cell growth
So how does Nerlynx work? According to the FDA, it’s a kinase inhibitor that works by blocking several enzymes that promote breast cancer
cell growth. To test the safety and efficacy of Nerlynx, FDA researchers studied its effects on 2,840 patients with early-stage, HER2-positive breast cancer in a randomised trial. They noted that these patients had completed their treatment with trastuzumab within the previous two years.
The study specifically measured the amount of time after the start of the trial that it took for the cancer to come back or for death to occur from any cause. The researchers discovered after two years that 94.2% of patients treated with Nerlynx hadn’t experienced cancer recurrence or death compared with 91.9% of those who received a placebo.
However, the researchers did note that Nerlynx can have side effects such as diarrhoea, nausea, vomiting, fatigue
, abdominal pain
and swelling, rash, swollen and sore mouth, muscle spasms, indigestion, decreased appetite, liver damage, dry skin, nail disorder, weight loss
and urinary tract infection.
For more information on this new HER2-positive breast cancer treatment, speak to your primary care physician.
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